Dehydrocostus Lactone
Dehydrocostus lactone (DHE), a natural sesquiterpene lactone, inhibits IKK? activity, I?B? phosphorylation and degradation, coactivators p300 recruitments and p50/p65 NF-?B nuclear translocation, and their DNA binding activity on COX-2 promoter. It has anti-inflammatory, anti-ulcer, immunomodulatory and anti-tumor properties.
