PHA-767491
PHA-767491 is a potent ATP-competitive dual Cdc7/CDK9 inhibitor with IC50 of 10 nM and 34 nM in cell-free assays, respectively.It displays ~20-fold selectivity against CDK1/2 and GSK3-?, 50-fold selectivity against MK2 and CDK5, 100-fold selectivity against PLK1 and CHK2.
