Apitolisib (GDC-0980, RG7422)
Apitolisib (GDC-0980, RG7422) is a potent, class I PI3K inhibitor for PI3K?/?/?/? with IC50 of 5 nM/27 nM/7 nM/14 nM in cell-free assays, respectively. Also a mTOR inhibitor with Ki of 17 nM in a cell-free assay, and highly selective versus other PIKK family kinases. Phase 2.
