OSI-027

OSI-027

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OSI-027 is a selective and potent dual inhibitor of mTORC1 and mTORC2 with IC50 of 22 nM and 65 nM in cell-free assays, and more than 100-fold selectivity observed for mTOR than PI3K?, PI3K?, PI3K? or DNA-PK. Phase 1.

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