Buparlisib (BKM120, NVP-BKM120)

Buparlisib (BKM120, NVP-BKM120)

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Buparlisib (BKM120, NVP-BKM120) is a selective PI3K inhibitor of p110?/?/?/? with IC50 of 52 nM/166 nM/116 nM/262 nM in cell-free assays, respectively. Reduced potency against VPS34, mTOR, DNAPK, with little activity to PI4K?. Phase 2.

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