Buparlisib (BKM120, NVP-BKM120)
Buparlisib (BKM120, NVP-BKM120) is a selective PI3K inhibitor of p110?/?/?/? with IC50 of 52 nM/166 nM/116 nM/262 nM in cell-free assays, respectively. Reduced potency against VPS34, mTOR, DNAPK, with little activity to PI4K?. Phase 2.
