Idelalisib (CAL-101, GS-1101)

Idelalisib (CAL-101, GS-1101)

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Idelalisib (CAL-101, GS-1101) is a selective p110? inhibitor with IC50 of 2.5 nM in cell-free assays; shown to have 40- to 300-fold greater selectivity for p110? than p110?/?/?, and 400- to 4000-fold more selectivity to p110? than C2?, hVPS34, DNA-PK and mTOR.

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