Ixazomib Citrate (MLN9708)

Ixazomib Citrate (MLN9708)

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Ixazomib Citrate (MLN9708) immediately hydrolyzed to MLN2238, the biologically active form, on exposure to aqueous solutions or plasma. MLN2238 inhibits the chymotrypsin-like proteolytic (?5) site of the 20S proteasome with IC50/Ki of 3.4 nM/0.93 nM in cell-free assays, less potent to ?1 and little activity to ?2. Phase 3.

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