Semagacestat (LY450139)

Semagacestat (LY450139)

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Semagacestat (LY450139) is a ?-secretase blocker for A?42, A?40 and A?38 with IC50 of 10.9 nM, 12.1 nM and 12.0 nM, also inhibits Notch signaling with IC50 of 14.1 nM in H4 human glioma cell. Phase 3.

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