Quizartinib (AC220)

Quizartinib (AC220)

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Quizartinib (AC220) is a second-generation FLT3 inhibitor for Flt3(ITD/WT) with IC50 of 1.1 nM/4.2 nM in MV4-11 and RS4;11 cells, respectively, 10-fold more selective for Flt3 than KIT, PDGFR?, PDGFR?, RET, and CSF-1R. Phase 3.

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