Ponatinib (AP24534) is a novel, potent multi-target inhibitor of Abl, PDGFR?, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM in cell-free assays, respectively.
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