Tandutinib (MLN518)

Tandutinib (MLN518)

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Tandutinib (MLN518, CT53518) is a potent FLT3 antagonist with IC50 of 0.22 ?M, also inhibits PDGFR and c-Kit, 15 to 20-fold higher potency for FLT3 versus CSF-1R and >100-fold selectivity for the same target versus FGFR, EGFR and KDR. Phase 2.

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