Tandutinib (MLN518)
Tandutinib (MLN518, CT53518) is a potent FLT3 antagonist with IC50 of 0.22 ?M, also inhibits PDGFR and c-Kit, 15 to 20-fold higher potency for FLT3 versus CSF-1R and >100-fold selectivity for the same target versus FGFR, EGFR and KDR. Phase 2.
