PF-06409577
PF-06409577 is orally bioavailable AMPK activator with EC50 of 7 nM for ?1?1?1 in the TR-FRET assay and it shows no detectable inhibition of hERG in a patch-clamp assay (100 ?M) and was not an inhibitor (IC50 > 100 ?M) of the microsomal activities of major human cytochrome P450 isoforms.
