FR 180204
FR 180204 is an ATP-competitive, selective ERK inhibitor with Ki of 0.31 ?M and 0.14 ?M for ERK1 And ERK2, respectively. It is 30-fold less potent against the related kinase p38? and failed to inhibit any kinases(MEK1, MKK4, IKK?, PKC?, Src, Syc, and PDGF?) at less than 30 ?M.
