Daminozide

Daminozide, a plant growth regulator, selectively inhibits the KDM2/7 JmjC subfamily with IC50 of 1.5±0.7 ?M for KDM2A. It is at least 100-fold selective as an inhibitor of the KDM2/7 subfamily over the other demethylase subfamily members tested, with IC50s of 2 ?M or less against KDM2A, PHF8, and KIAA1718 and IC50s of 127 ?M for KDM3A or greater (mM range) against other demethylases.